In sipple syndrome [MEN II ) all are present except:
Correct Answer: Pituitary hyperplasia
Description: Ans: b (Pituitary hyperplasia) Ref: Robbins, 7th ed,p. 222MEN 2a is characterized by pheochromocytoma, medullary carcinoma thyroid, and Parathyroid hyperplasia SYNDROMES MEN IMEN IIAMEN II BPituitaryParathyroidAdenomaHyperplasiaAdenomaCarcinomaHyperplasia Adrenal thyroidCortical hyperplasiaPheochromocytomaC cell hyperplasiaMedullary carcinomaPheochromocytomaC cell hyperplasiaMedullary carcinomaExtra endocrine changes MucocutaneousGanglioneuromaMarfanoid habitusMutant geneMEN IRETRETHirschsprung disease - loss of function in RET proto-oncogeneMEN IIA - a gain of function in RET proto-oncogene
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