In hyperventilation:

A. P50 and Hb affinity for O2 increases

B. P50 and Hb affinity for O2 decreases

C. P50 increases and O2 affinity decreases

D. P50 decreases and O2 affinity increases

Correct Answer: P50 decreases and O2 affinity increases

Description: Hyperventilation washes out CO2 from body, leadng to alkalosis.So, Oxygen hemoglobin dissociation curve will shift to left (high affinity), decreasing P50 of hemoglobin. Reference: Ganong’s Review of Medical Physiology 24th edition pg 611

Category: Physiology

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