Total colonic aganglionosis is a variant of?
Correct Answer: Hirschsprung's disease
Description: Ans. is 'c' i.e., Hirschsprung's disease * Hirschprung disease (Congenital aganglonic megacolon) is caused by defective migration of neural crest into the mesodermal layer of gut. There is aganglionosis (absence of ganglions) in a portion of intestinal tract. Intestinal segment lacks both Meissner submucosal and Auerbach myenteric plexuses.* Total colonic aganglionosis (Zuelzer Wilson syndrome) is particular variant of Hirschsprung's disease (5-8% cases) in which aganglionic portion extends to entire length of colon. In rare cases aganglionosis may extent from duodenum to rectum.
Category:
Pathology
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