Mechanism of action of triazoles is:
Correct Answer: Inhibit ergosterol synthesis
Description: Ans. (A) Inhibit ergosterol synthesis(Ref: Goodman and Gilman 13th/e p1091)Anti-fungal drug groupExampleMechanismPolyeneAmphotericin BCreate artificial pores in membrane by binding to ergosterolAzoles (Imidazole and triazoles)FluconazoleItraconazoleInhibit Lanosterol-14- alpha-demethylaseAllylaminesTerbinafineButenafineInhibit squalene epoxidaseAnti-metabolite5-FlucytosineInhibit DNA formationBenzofuranGriseofulvinBinds to tubulin and inhibit mitosisEchinocandinsCaspofungin MicafunginInhibit beta 1,3 glycan in fungal cell wall
Category:
Pharmacology
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