In G6PD deficiency patient, hemolysis is due to decrease in
Correct Answer: NADPH
Description: G6PD deficiency is an inherited sex-linked trait. Although the deficiency occurs in all the cells of the affected individuals, it is more severe in RBC. HMP shunt is the only means of providing NADPH in the erythrocytes. Decreased activity of G6PD impairs the synthesis of NADPH in RBC. This results in the accumulation of methemoglobin and peroxides in erythrocytes leading to hemolysis.
Glucose-6-phosphate dehydrogenase deficiency is most common and pyruvate kinase deficiency is 2nd most common enzyme deficiency related hemolytic anemia.
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now