Which of the following causes hemolytic anemia -a) Hereditary spherocytosisb) Infectionc) Iron deficiencyd) Sickle cell anemiae) Copper deficiency
Correct Answer: abd
Description: Hemolytic anemia may be of two types.
Intracorpuuscular
Underlying cause of hemolysis is intrinsic to RBC, e.g.,
Defect in membrane cytoskeleton → Hereditary spherocytosis
Defect in red cell enzyme → G6PD deficiency.
Disorder of hemoglobin synthesis
Deficient globin synthesis →Thalassemia
Structurally abnormal globin → Sickle cell anaemia.
(hemoglobinopathies)
Membrane defect → Paroxysmal nocturnal hemoglobinuria
2. Extracorpuscular
Underlying cause of hemolysis is extrinsic, ie., not within RBC, e.g., : -
Immunohemolytic anemia
Microangiopathic hemolytic anemia → (i) TTP, (ii) HUS, (iii) DIC
Infection → Malaria
Mechanical trauma to RBC → rosthetic valve.
Hyperspienism
Category:
Pathology
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