All of the following are seen in Goodpasture’s syndrome, except:
Correct Answer: Diffuse alveolar involvement
Description: Goodpasture syndrome Type II hypersensitivity reaction) Presence of antibodies against non-collagenous domain of a3 chain of collagen IV causing destruction of basement membrane in renal glomeruli and pulmonary alveoli. Histologically, the alveoli show focal necrosis (not diffuse involvement), intra-alveolar hemorrhage, presence of hemosiderin laden macrophages and hyperophy of type II Pneumocytes.
Category:
Pathology
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