Cytokines are secreted in sepsis and Systemic Inflammatory Response syndrome (SIRS) by –
Correct Answer: Neutrophils
Description: Cytokine release in Sepsis
The mechanism by which endotoxin causes activation of inflammatory cells and release of cytokines has already been explained earlier.
It is by TL -4 and CD-14 mediated.
Signals from TLR-4 can directly activate vascular endotheliun and leukocytes to release cytokine mediators.
The major cells that secrete cytokines in sepsis area
Monocyte/Macrophages
Neutrophils
Endothelial cells
Cytokine mediators involved are:-
TNF - (The most important cytokine in sepsis)
IL-1
IL-6
IL-8
NO.
Category:
Pathology
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