VHL syndrome is associated most commonly with which carcinoma –
Correct Answer: Renal cell carcinoma
Description: Von Hippel-Lindau (VHL) syndrome: VHL gene is a tumor suppressor gene and is involved in the development of both familial and sporadic clear cell carcinoma. VHL patients develop bilateral renal cysts and multiple renal cell carcinomas. Both sporadic and familial RCC is associated with: Loss of sequence on chromosome 3 either by translocation (3:6, 3:8, 3:11) or deletion. This region harbors the VHL gene. Familial RCC is associated with:- Von Hippel-Lindau syndrome VHL syndrome: Autosomal dominant cancer syndrome, characterized by: Cerebellar hemangioblastomas Retinal angiomas Clear cell RCC Pheochromocytoma Cysts in various organs. Ref: RAM DAS NAYAK EXAM PREPARATORY MANUAL FOR UNDERGRADUATES 2nd ed. pg no: 633
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now