Busulfan may cause: September 2007
Correct Answer: Pulmonary fibrosis
Description: Ans. B: Pulmonary Fibrosis Toxicity of busulphan may include: Interstitial pulmonary fibrosis Hyperpigmentation Seizures Hepatic (veno-occlusive disease) Wasting syndrome. Phenytoin may be used concurrently to prevent the seizures. Levetiracetam, has shown efficacy for the prophylaxis against busulfan-induced seizures. Benzodiazepines can also be used for busulfan-induced seizures.
Category:
Pharmacology
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