An 80-year-old female who has never taken estrogen, develops pink vaginal discharge. An endometrial biopsy shows an adenocarcinoma of the endometrium. Papanicolaou smear is negative. Of the following what is the most important indicator of prognosis?
Correct Answer: Histologic type of tumour
Description: Prognostic factors in endometrial adenocarcinoma
Most important prognostic factor is lymph node metastasis
Age at diagnosis (older the patient poorer the prognosis).
Stage of the disease.
Histologic type (endometriod adenocarcinoma have good prognosis, clear cell carcinoma have poor prognosis).
Histologic grade .
Myometrial penetration (Increasing depth of invasion is associated with increasing likelihood of extrauterine spread and recurrence).
Extension to cervices, Involvement of cervix, isthmus or both is associated with increased risk of extrauterine disease and LN metastasis.
Tumor size (> 2 cm-more lymph node metastasis).
Hormone receptor status (receptor positive-better prognosis).
Ploidy status: Aneuploid have got better prognosis compared to diploid tumors.
Oncogene expression: HER: 2/neu, k-ras poor prognosis.
Role of Peritoneal cytology on prognosis is controversial.
Category:
Gynaecology & Obstetrics
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now