All of the following are true about Wilson disease, except
Correct Answer: Liver damage begins at the age of 18
Description: There is impaired biliary copper excretion, resulting in positive copper balance, hepatic copper accumulation. Excess hepatic copper leads to liver damage, which begins as early as three years of age. Serum copper levels are usually lower than normal because of low blood ceruloplasmin. As the disease progresses, non ceruloplasmin serum copper ("free" copper) levels increase which leads to copper buildup in other pas of the body, such as the brain, leading to neurologic and psychiatric disease. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 3188
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