Bile salts undergo xenobiotics:
Correct Answer: After conjugation with betaglucuronic acid
Description: C i.e. Conjugation with betaglucuronic acid- Phase I biotransformation reactions include Hydrolysis, Hydroxylation, Reduction, Oxidation, Oxidative Deamination, Dealkaylation and Epioxidation. Mn "High RODE". Whereas phase II reactions include Glucronidation, Sulfation, Conjugation (with glucronic acid, glutathione, sulfate or aminoacids), Acetylation and Methylation. Mn "5G-SCAM".Cytochrome p450 monoxygenase is the main enzyme responsible for activation of xenobiotics (phase I hydroxylation reaction)Q.Bilirubin is metabolized like xenobiotics; it is conjugated with beta glucronic acid in hepatocytes to conve a nonpolar hydrophobic bilirubin to a polar hydrophilic one which is readily excreted in bileQ.
Category:
Biochemistry
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