A 10-year-old boy with a 2-week history of an upper respiratory infection was admitted to the hospital with malaise, fever, joint swelling and diffuse rash. The patient is treated and discharged. However, the patient suffers from recurrent pharyngitis and a few years later, develops a hea murmur. This patient’s hea murmur is most likely caused by exposure to which of the following pathogens?
Correct Answer: Beta-hemolytic streptococcus
Description: Rheumatic fever develops after antibodies to surface antigens of group A (beta-hemolytic) streptococci cross react with similar antigens found in the hea, joints and connective tissue of the skin. Cardiac lesions caused by acute rheumatic fever include endocarditis, myocarditis and pericarditis, or all three combined. Chronic rheumatic endocarditis causes fibrous scarring and deformity of cardiac valves, leading to hea murmurs and functional defects. None of the other pathogens cause rheumatic hea disease.
Category:
Pathology
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