A macroscopic hepatic change known as nutmeg liver is indicative of ?
Correct Answer: Chronic congestive hea failure
Description: Chronic hea failure results in blood stasis in the central veins and central sinusoids of hepatic lobules, with subsequent central hemorrhagic necrosis. Thus, the red central regions compared with the surrounding tan-brown ble parenchymal impa the mottled appearance of a nutmeg to the liver cut surface. Acute left-sided hea failure gives rise to acute pulmonary edema, with extravasation of plasma and red blood cells into alveolar spaces. Acute right-sided hea failure leads to acute congestion of the liver, which does not acquire the typical nutmeg appearance as in chronic congestion. Alcohol toxicity leads to a number of hepatic alterations. Fatty change results from alteration in lipoprotein metabolism, leading to accumulation of fats as a large single droplet within the cytoplasm of hepatocytes (microvesicular steatosis). Alcoholic hepatitis is an acute response to alcohol abuse and is associated with hepatocyte necrosis and formation of Mallory bodies. Long-standing alcohol toxicity may cause a peurbation of the liver architecture leading to liver cirrhosis. Ref: Mohrman D.E., Heller L.J. (2010). Chapter 11. Cardiovascular Function in Pathological Situations. In D.E. Mohrman, L.J. Heller (Eds), Cardiovascular Physiology, 7e.
Category:
Physiology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now