What constitutes malpighian layer of skin?
Correct Answer: Spinosum and basale
Description: Ref. Rook's Textbook of Dermatology, Pg 35
Histology of skin
Basal layer:
Mitotically active, produces other keratinocytes
Contains low molecular weight keratin
Separated from dermis by continuous basal membrane; keratinocytes are attached to this membrane by hemidesmosomes
Also contains melanocytes
Squamous layer (stratum spinosum):
Also called prickle or malpighian layer
Has several layers of cells, larger than basal layer, which become flat and eosinophilic as they approach the surface due to an increase in keratin and reduction in ribosomes
May have clear vacuolated cytoplasm
Cells are attached to each other by fine spiny bridges with central dot-like desmosomes (Bizzozero’s nodule)
Loss of spiny bridges causes acantholysis
Granular layer (stratum granulosum):
1 - 3 layers of flattened cells with intensely basophilic keratohyaline granules, which contain precursors of filaggrin protein, which causes aggregation of keratin filaments
Malphigian layer includes – spinosum and granulosum
Stratum lucidum:
Present only in soles and palms, between granular and cornified layer
Homogenous eosinophilic zone
Cornified layer (stratum corneum):
Also called horny layer
Basket weave pattern of multiple layers of polyhedral cells without nuclei
Region is thicker and more compact in acral region (peripheral body-limbs, fingers, ears)
Rete ridges:
Undulating forms of epidermis and dermal papillae at dermoepidermal junction - flattens with aging
Category:
Unknown
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