All of the following statements about Penicillin resistance are true, Except –
Correct Answer: Alteration in target PBPs is an impoant resistance mechanism in gram negative bacteria
Description: Ans. is b i.e., Alteration in target PBPs is an impoant resistance mechanism in gram negative bacteria PENICILLIN RESISTANCE o Mechanism of resistance are ? Penetration into the cell o Gram negative bacteria have an outer membrane just outside the cell wall. o Outer membrane is not present in gram positive bacteria, so this mechanism of resistance is not for gram positive organisms. beta-lactamase (Penicillinase) Production o This is the most common mechanism o Both gram positive and gram negative organism produce beta-lactamase which open the beta-lactam ring and inactivate the antibiotic. Altered penicillin bindinE protein (PBP) o Bacteria can alter the structure of penicillin binding protein, which is not other than transpeptidase. o So, penicillin can not bind to the site where it acts. o MRSA defends itself in this way. o Organism resistant to methicillin, MRSA is resistant to all other beta-lactam antibiotics.
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