IL-1 is activated by
Correct Answer: Caspase 1
Description: * Pyroptosis is associated with release of cytokine IL 1 * Microbial products that enter the cytoplasm of the cell are recognised by cytoplasmic immune receptors and activates a multiprotein complex called INFLAMMASOME * Inflammasome will activate CASPASE 1 (also called Interleukin 1 beta conveing enzyme) and releases the active form of IL 1 * Several NORs (NOD like receptor) signal INFLAMMASOME * Gain of function in NLR can cause periodic fever syndromes called AUTO INFLAMMATORY SYNDROMES * They respond to IL-1 antagonists * IL 1 activates fibroblasts to synthesize collagen and stimulates the proliferation of mesenchymal cells * IL 1 also stimulates Th17 responses * Initiator caspase in Intrinsic pathway of apoptosis - IL 9 * Initiator caspase in Entrinsic pathway of apoptosis - IL 8, 10 * Executioner caspase of apoptosis IL 3 & IL 7 Ref:- Robbins Basic Pathology 9th Edition; Pg num:- 59,86,188
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now