Which of the following is the drug of choice for medication-resistant schizophrenia: September 2009
Correct Answer: Clozapine
Description: Ans. C: Clozapine Clozapine It may inhibit serotonin, muscarinic, and dopamine effects. Revolutionized treatment of medication-resistant schizophrenia. Effective in 30% of patients in whom other medications have failed. May improve tardive dyskinesia resulting from long-term use of traditional antipsychotics. Major drawback of reversible agranulocytosis occurs in 1-2% Interactions-Epinephrine and phenytoin may decrease effects; tricyclic antidepressants, neuroleptics, CNS depressants, guanabenz, and anticholinergics may increase effects Contraindications-Documented hypersensitivity; WBC (less than 3500 cells per millimeter cube) before or during therapy. Precautions-Pregnancy, Do not abruptly stop the medication; to minimize risk of agranulocytosis.
Category:
Psychiatry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now