Monoclonal antibody to IL-5 is:
Correct Answer: Mepolizumb
Description: IL5 antagonists- reslizumab, mepolizumab, benralizumab(IL5 receptor antagonist) MEPOLIZUMAB: Mechanism of Action Humanized IgG1 kappa monoclonal antibody specific for IL-5; binds IL-5, and therefore stops IL-5 from binding to its receptor on the surface of eosinophils Inhibiting IL-5 binding to eosinophils reduces blood, tissue, and sputum eosinophil levels Absorption- Bioavailability: 80% Elimination Half-life: 16-22 days Systemic clearance: 0.28 L/day use:Asthma Indicated for add-on maintenance treatment of patients with severe asthma aged >=12 yr, and with an eosinophilic phenotype 100 mg SC q4wk Dosing Considerations Not for the treatment of other eosinophilic conditions Not for relief of acute bronchospasm or status asthmaticus Adverse Effects- headache MOST common REF KD Tripathi 8th ed
Category:
Pharmacology
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