Gilbe syndrome, true all except
Correct Answer: Causes cirrhosis
Description: Gilbe's Syndrome This is the commonest of the familial, genetically-determined diseases of the liver affecting 2-5% of the population. Gilbe's syndrome is characterised by mild, benign, unconjugated hyperbilirubinaemia (serum bilirubin 1-5 mg/dl) which is not due to haemolysis. The condition is inherited as an autosomal dominant character. The defect in bilirubin metabolism is complex and appears to be reduced activity of UDP-glucuronosyl transferase with decreased conjugation, or an impaired hepatic uptake of bilirubin. The jaundice is usually mild and intermittent. MORPHOLOGIC FEATURES: There are no morphologic abnormalities in the liver except some increased lipofuscin pigment in centrilobular hepatocytes. The prognosis of patients with Gilbe's syndrome is excellent, though chronic jaundice persists throughout life. TEXTBOOK OF PATHOLOGY 6TH EDITION HARSH MOHAN PAGE NO:600
Category:
Pathology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now