Metabolic bone disease is caused by excess intake of which vitamin?
Correct Answer: A
Description: Metabolic bone disease is caused by excess intake of vitamin -A.Retinoic acid has a role in the regulation of gene expression and differentiation of tissues. All-trans-retinoic acid and 9-cis retinoic acid act like steroid hormones. They bind to nuclear receptors; retinoic acid along with the receptor binds to the response elements of DNA. Retinoic acid receptors (RAR) bind all-trans-retinoic acid, while retinoic x receptors (RXR) bind to 9-cis-retinoic acid. RXRs form dimers with vitamin D-receptor also. This explains why deficiency of vitamin A impairs vitamin D function; when there is lack of 9-cis-retinoic acid to receptor dimers, vitamin D function is not optimal.Ref: DM Vasudevan - Textbook of Biochemistry, 6th edition, page no: 382,383
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now