Genetic abnormality in case of late adenoma to carcinoma in Ca colon:
Correct Answer: p53
Description: The most frequently mutated tumor suppressor gene in human neoplasia is p53 (TP53), located on chromosomes 17p. Mutations in p53 are present in 75% of colorectal cancers and occurs, rather late in the adenoma-carcinoma sequence. FEARON - VOGELSTEIN ADENOMA CARCINOMA MULTISTEP MODEL
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