The molecular basis of penicillin resistance in S.Pneumoniae is:
Correct Answer: Alteration of penicillin-binding protein
Description: The molecular basis of penicillin resistance in S. pneumoniae is the alteration of penicillin-binding protein (PBP) genes which result in lower affinity for penicillins. Penicillin G is the drug of choice for disease caused by susceptible organisms, including community-acquired pneumonia. Ref: Harisson, Edition - 18, Page 1156
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