Testing of HLA-B*57:01 is recommended prior to the initiation of this anti-retroviral agent
Correct Answer: Abacavir
Description: Ref. KDT. Page. 808
Abacavir
It is a potent ARV drug that acts after intracellular conversion to carbovir triphosphate.
Resistance to ABC develops slowly
Its oral bioavailability is 80% and it is mainly eliminated by metabolism.
The plasma t1⁄2 is 1–1.5 hour, but intracellular t1⁄2 of active metabolite is >12 hours.
Hypersensitivity reactions such as rashes, fever, flu-like symptoms are the major problems.
To avoid anaphylactic reactions in response to the drug HLA-B*57:01 testing is mandatory pre-treatment.
Avoidance of alcohol is advised.
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