Which drug inhibits absorption of cholesterol from intestine?
Correct Answer: Ezetimibe
Description: ANSWER: (B) EzetimibeREF: Harrison's 18th ed ch: 356Cholesterol ivithin the lumen of the small intestine is derived from the diet (about one-third) and the bile (about two-thirds) and is actively absorbed by the enter ocyte through a process that involves the protein N PCI LI.Ezetimibe is a cholesterol absorption inhibitor that binds directly to and inhibits NPCILI and blocks the intestinal absorption of cholesterol. Ezetimibe (10 mg) inhibits cholesterol absorption by almost 60%, resulting in a reduction in delivery of dietary sterols in the liver and an increase in hepatic LDL receptor expression.The mean reduction in plasma LDL-C on Ezetimibe (10 mg) is 18%, and the effect is additive when used in combination with a statin. Effects on triglyceride and HDL-C levels are negligible, and no cardiovascular outcome data have been reported.When used in combination with a statin, monitoring of liver transaminases is recommended. The only role for Ezetimibe in monotherapy is in patients who do not tolerate statins; the drug is often added to a statin in patients who require further LDL-C reduction.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now