In sickle cell anaemia, the mutational event responsible for the mutation for beta chain is –

Correct Answer: Point mutation
Description: In sickle cell disease there is single nucleotide change in the B globin gene leading to substitution of valine for glutamate at position 6 of the B globin chain, this is point mutation. Ref:Postgraduate Hematology by Victor Hoffbrand pg :109
Category: Pathology
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