A 24 year old patient presented with unexplained weight loss and fever. Routine examinations shows elevated liver function tests. USG shows a growth in the liver which is confirmed as fibrolamellar carcinoma of the liver. What is NOT true about fibrolamellar carcinoma of the liver?
Correct Answer: APF levels > 1000
Description: Fibrolamellar carcinoma of the liver is typically a disease of younger adults, often teenagers and predominantly females. It is AFP-negative, but patients typically have elevated blood neurotensin levels, normal liver function tests, and no cirrhosis. Radiology is similar for HCC, except that characteristic adult-type poal vein invasion is less common. Although it is often multifocal in the liver, and therefore not resectable, metastases are common, especially to lungs and locoregional lymph nodes, but survival is often much better than with adult-type HCC. Ref: Qamar A.A., Ukomadu C. (2012). Chapter 49. Liver Neoplasms. In R.S. Blumberg, R. Burakoff (Eds), CURRENT Diagnosis & Treatment: Gastroenterology, Hepatology, & Endoscopy, 2e
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