Which of the following condition is associated with polycystic ovaries?
Correct Answer: Adrenal hyperplasia
Description: Women with Cushing syndrome, congenital adrenal hyperplasia, and androgen-secreting adrenal tumors also tend to have high circulating androgen levels and anovulation with polycystic ovaries. In this late-onset form of congenital adrenal hyperplasia (CAH), the enzyme deficiency leads to a relative coisol deficiency. In response, adrenocoicotropic hormone (ACTH) levels are increased to normalize coisol production. Adrenal hyperplasia and elevated androgens results as a consequence of this accommodation. Thus, symptoms of late-onset CAH reflect accumulation of precursor C19 steroid hormones. These precursors are conveed to dehydroepiandrosterone, androstenedione, and testosterone. Thus, signs of virilization predominate. Ref: Hoffman B.L., Schorge J.O., Schaffer J.I., Halvorson L.M., Bradshaw K.D., Cunningham F.G., Calver L.E. (2012). Chapter 17. Polycystic Ovarian Syndrome and Hyperandrogenism. In B.L. Hoffman, J.O. Schorge, J.I. Schaffer, L.M. Halvorson, K.D. Bradshaw, F.G. Cunningham, L.E. Calver (Eds), Williams Gynecology, 2e.
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Gynaecology & Obstetrics
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