A middle aged man operated for testicular cancer. Histological examination shows primitive looking “ugly” cells with abundant mitotic cells. The tumor cells are positive for cytokeratin and CD30. The type of tumor is:
Correct Answer: Embryonal carcinoma
Description: Microscopically, embryonal carcinoma cells are the most undifferentiated of the GCT types and are characterized by alveolar or tubular architecture; pleomorphic, primitive looking "ugly" cells with abundant mitotic figures. Phenotypic characterization can reveal positivity for cytokeratin, CD30, PLAP, AFP, and hCG. Modest elevations of both AFP and hCG are typical, but impoantly, pure embryonal cancers can be marker-negative in the serum. Ref: Wyatt C., Butterwoh IV J.F., Moos P.J., Mackey D.C., Brown T.G. (2008). Chapter 17. Pathology of the Male and Female Reproductive Tract and Breast. In C. Wyatt, J.F. Butterwoh IV, P.J. Moos, D.C. Mackey, T.G. Brown (Eds), Pathology: The Big Picture.
Category:
Surgery
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now