Which of the following is not a side effect ofnaloxone
Correct Answer: >Seizure
Description: Seizure Opioid antagonists Naloxone is an opioid antagonists Under ordinary circumstances in normal individuals it does not produce any discernible effect. - It produces its effects only when agonistic opioids have been administered earlier to the patient. - However, if endogenous opioid system is activated as in shock or ceain forms of stress, the administration of opioid antagonist alone may have ble consequences. Naloxone is an opioid antagonist and it promptly reverses the respiratory depressant propey of opioids. - Other agnostic effects of opioids such as effects. on CNS and blood pressure is also reversed by opioids. - Naloxane is commonly used to reverse respiratory depression produced by opioid. The antagonism of opioid effects by naloxone is often accompanied by "overshoot" phenomenon i.e.,while reversing the effect produced by the opioids it tends to overcorrect it. - The respiratory rate depressed by opioids transiently become higher than that before the period of depression. - Rebound release of catecholamine may cause "hypeension", "tachycardia" and "ventricular arrhythmias". - "Pulmonary edema" has also been repoed after naloxone administration. Naloxone may precipitate seizures but they are seen only in patients who are addicted to or dependent on opioids. - Small subcutaneous doses of naloxone precipitates a moderate to severe withdraw! syndrome that is very similar to that seen after abrupt withdrawl of opioids excepts that the syndrome appears within minutes of administration and subsides in about 2 hours. - However, seizure cannot be considered an adverse effect of naloxone. Seizure occur as a pa of withdrawl syndrome when naloxone is administered to those who are addicted or dependent on opioids. When naloxone is administered in nonnal individuals to treat opioid overdose, it does not precipitate withdrawl syndrome and seizures do not occur. - On the other hand the cardiac effects i.e., arrhythmia, hyper- tension and pulmonary edema are produced when naloxone is administered in normal individual to reverse the effect of opioids. - These effects do not require the prior administration of opioids.
Category:
Pharmacology
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