Which of the following statements about anti-epileptics is false?

A. Phenytoin and carbamazepine act by prolonging the inactivated state of Na+ channels

B. Carbamazepine can be used in trigeminal neuralgias

C. Diazepam is an anticonvulsant drug

D. Lamotrigine mainly acts by causing GABA mediated Cl- channel opening

Correct Answer: Lamotrigine mainly acts by causing GABA mediated Cl- channel opening

Description: prolongation of Na+ channel inactivation and suppression of high frequency firing has been demonstrated. In addition, it may directly block voltage sensitive Na+ channels, thus stabilizing the presynaptic membrane and preventing release of excitatory neurotransmitters, mainly glutamate and aspaate. Ref KD Tripati 8thh ed.

Category: Pharmacology

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