Predisposing features for germ cell tumour-a) Cryptorchidismb) Testicular feminising syndromec) Klinefelter’s syndromed) Smokinge) Right side more common than Left side
Correct Answer: abce
Description: The predisposing factor of germ cell tumors of testes are :
Cryptorchidism
Testicular feminisation syndrome
Klinefelter syndrome
Excess 12P copy number either in the term of i( 12P) or increased 12P an aberranthy banded marker chromosome.
In most large testicular tumour approximately 10% associated with Cryptorchidism.
Abdominal cryptorchid testes are higher risk than inguinal cryptorchid testes.
Early orchiopexy before puberty reduced the risk of GCT.
Klinefeleter's syndrome is associated with mediastinal GCT.
An ischromosome of short arm of chromosome 12. is pathognomic of GCT in all histological types
Category:
Pathology
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