The mechanism of action of sodium nitroprusside is?
Correct Answer: Increased guanylate cyclase
Description: Ans. is 'b' i.e., Increases Guanyl Cyclase o "Nitroprusside dilates both aerial and venous vessels, resulting in reduced peripheral vascular resistance and venous return. The action occurs as a result of activation of guanylyl cyclase, either release of nitric oxide or by direct stimulation of enzyme. The result is increased intracellular cGMP, which relaxes vascular smooth muscle".
Category:
Pharmacology
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