Glomerulonephritis is a feature of all except :
Correct Answer: Diabetic nephropathy
Description: Ans: b) Diabetic nephropathyDiabetic nephropathy refers to conglomerate of lesions that occur concurrently in the diabetic kidney.Most common glomerular syndrome include:1) Non nephrotic proteinuria2) Nephrotic syndrome3) Chronic renal failureArteriolar lesion is hyalinizing arteriosclerosis; increased chance of pyelonephritis and papillary necrosis.Earliest change in DM is the thickening of the glomerular basement membraneMost common pattern of involvement is Diffuse glomerulosclerosisInfective Endocarditis:Glomerulonephritis is an immunological phenomena in IEImmunological phenomena in IE = ROGRRoth's spotsOsiers nodesGlomerulonephritisRheumatoid factorAlport syndrome:Characterised by hereditary nephritis progressing to chronic renal failure, sensory neural hearing loss and eye disorders including lens dislocation, posterior cataract and corneal dystrophy.Alport syndrome mutation is COL4A5 of GBMThin Basement membrane disease - COL4A3, COL4A4 of GBM (BM thickening 150 -250nm)Nail patella syndrome: (LMX1B mutation)Characterized by hypoplastic or aplastic patellae, dislocated radial head and progressive nephropathy.Renal manifestations in nail patella syndrome include proteinuria (sometimes NS), hematuria, and hypertension.Urine concentrating ability may be impaired.Other collagen mutations and diseases associated:COL1A1 : Osteogenesis imperfectaCOL2A1 : Achondrogenesis!!, hypochondrogenesis, Stickler syndromeCOL9A2 : Multiple epiphyseal dysplasiaCOL10A1 : Schmid metaphyseal chondrodysplasia
Category:
Pathology
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