A 40-year-old woman has lipid investigations suggesting familial hypercholesterolemia (increased cholesterol, increased low-density lipoprotein , and normal triglycerides). This condition is characterized by increased risk for premature atherosclerosis and by the occurrence of tuberous and tendon xanthomas. Before making the assumption of familial hypercholesterolemia, secondary causes need to be considered. Which of the following conditions is most likely to cause secondary hyperlipidemia?
Correct Answer: cholestatic liver disease
Description: Important secondary causes include DM, obesity/dietary intake, hypothyroidism, renal disease (nephritic syndrome), and cholestatic liver disease. Alcohol in small amount improves lipid profiles and in excess causes increase in triglycerides. Estrogen too improves lipid profiles. The other choices are not important in affecting lipid levels.In familial hypercholesterolemia, there is an increased incidence of CAD, and hypercholesterolemia occurs along with tuberous xanthomas, arcus senilis, and atheromas. Most affected individuals are heterozygous for the mutant gene.
Category:
Medicine
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now