All of the following statements regarding penicillin-G are true, EXCEPT:

A. Can be given orally

B. Active against gram positive organisms

C. Probenecid given along with penicillin-G increases its duration of action

D. Acts by inhibition of cell wall synthesis

Correct Answer: Can be given orally

Description: Penicillin G is acid labile and it is destroyed easily by gastric acid, and hence it can only be given parenterally (intravenously or intramuscularly) and not orally. Ref: KDT, 6th Edition, Pages 696-97 ; Streptococcal Pharyngitis: Optimal Management By Jean Claude Pechere, 3rd Volume, Page 188 ; Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk By Gerald Briggs, Roger K. Freeman, Sumner J. Yaffe, Page 205

Category: Pharmacology

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