A patient of anemia due to chronic inflammation, the positive finding is
Correct Answer: Serum iron is increased
Description: Direct quote from Robbins : ‘Hyperacute rejection occurs when preformed antidonor antibodies are present in the circulation of the recipient’. Such antibodies may be present:
In a recipient who has previously rejected a kidney transplant
Multiparous women who develop anti-HLA antibodies against paternal antigens shed from the fetus may have preformed antibodies to grafts taken from their husbands or children
Prior blood transfusions
In recipients not previously sensitized to transplantation antigens, exposure to the class I and class II HLA antigens of the donor graft may evoke antibodies. The initial target of these antibodies in rejection seems to be the graft vasculature.
Thus, antibody-dependent acute humoral rejection is usually manifested by a vasculitis, sometimes referred to as rejection vasculitis
Category:
Pathology
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