Cyanide taken up by child. First one to be affected in Kreb’s cycle is?
Correct Answer: NAD
Description: Cyanide inhibits complex IV of ETC. So, if ETC is inhibited and NADH accumulates. If NADH accumulates, it means NAD depleted. So, TCA is affected because each TCA cycle requires 3 NAD (for Isocitrate Dehydrogenase, alpha-ketoglutarate dehydrogenase and Malate Dehydrogenase). Extra information: Cyanide poisoning: Cyanide is probably the most potent inhibitor of ETC (Complex IV). It binds to Fe3+ of cytochrome oxidase blocking mitochondrial respiration leading to cell death. Cyanide poisoning causes death due to tissue asphyxia (mostly of the central nervous system).
Category:
Biochemistry
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now