Which of the following statement is not true about NSAIDs

A. Acetylsalicylic acid is an Irreversible inhibitors of Cox enzyme acetylsalicylic acid is an Irreversible inhibitors of Cox enzyme

B. Acetylsalicylic acid reduces in Vivo synthesis of prostaglandins

C. Its clearance is independent of Plasma concentration

D. Antiplatelet effect of low dose aspirin is related to pre systemic Cox inhibition

Correct Answer: Its clearance is independent of Plasma concentration

Description: Acetylsalicylic acid (asprin) is an Irreversible inhibition of COX enzyme. IT results in inhibition of prostaglandin and TX synthesis at low doses for (40 to 325 milligrams) it exes antiplatelet action. this drug shows saturation kinetics at high doses that is kinetics changes from first order to zero order. therefore at high doses amount of drug exeed will be constant that means clearance il is not constant. Refer kDT 6/e p185

Category: Pharmacology

Share:

← Previous MCQ

Next MCQ →

Get More

Subject Mock Tests

Practice with over 200,000 questions from various medical subjects and improve your knowledge.

Attempt a mock test now

Mock Exam

Take an exam with 100 random questions selected from all subjects to test your knowledge.

Coming Soon

Get More

Subject Mock Tests

Try practicing mock tests with over 200,000 questions from various medical subjects.

Attempt a mock test now

Mock Exam

Attempt an exam of 100 questions randomly chosen from all subjects.

Coming Soon