All is true about ropivacaine except:
Correct Answer: Cardiotoxicity is similar to as that of Bupivacaine
Description: Ropivacaine is a long-acting amide local anaesthetic agent and first produced as a pure enantiomer. It produces effects similar to other local anaesthetics reversible inhibition of sodium ion influx in nerve fibres. Ropivacaine is less lipophilic than bupivacaine and is less likely to penetrate large myelinated motor fibres, resulting in a relatively reduced motor blockade. Thus, ropivacaine has a greater degree of motor sensory differentiation, which could be useful when motor blockade is undesirable. The reduced lipophilicity is also associated with decreased potential for central nervous system toxicity and cardiotoxicity. The drug displays linear and dose propoional pharmacokinetics (up to 80 mg administered intravenously). It is metabolised extensively in the liver and excreted in urine.
Category:
Anaesthesia
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