All of the following are tumor necrosis factor blocking agents, EXCEPT:
Correct Answer: Abciximab
Description: Abciximab is a chimeric antibody that binds irreversibly to the GP IIb/IIIa antagonists. Etanercept is a human TNF receptor fusion protein consisting of two molecules of the ligand-binding poion of the TNF receptor (p75) fused to the Fc poion of IgG1. Etanercept binds soluble and membrane-bound TNF, thereby inhibiting the action of TNF. Infliximab is a mouse-human chimeric IgG1 monoclonal antibody that binds to soluble and membrane-bound TNF-. Infliximab is a complement-fixing antibody that induces complement-dependent and cell-mediated lysis when bound to cell-surface-bound TNF-. Adalimumab is a human IgG1 monoclonal antibody that binds soluble and membrane-bound TNF-. Like infliximab, it can mediate complement-induced cytolysis of cells expressing TNF. Ref: Burkha C., Morrell D., Goldsmith L. (2011). Chapter 65. Dermatological Pharmacology. In L.L. Brunton, B.A. Chabner, B.C. Knollmann (Eds), Goodman & Gilman's The Pharmacological Basis of Therapeutics, 12e.
Category:
Pharmacology
Get More
Subject Mock Tests
Practice with over 200,000 questions from various medical subjects and improve your knowledge.
Attempt a mock test nowMock Exam
Take an exam with 100 random questions selected from all subjects to test your knowledge.
Coming SoonGet More
Subject Mock Tests
Try practicing mock tests with over 200,000 questions from various medical subjects.
Attempt a mock test now