True about G protein-coupled receptors is

A. G proteins bind to hormones on the cell surface

B. All the three subunits alpha, beta and gamma should bind to each other for G protein to act

C. G proteins act as inhibitory and excitatory because of difference in alpha subunit

D. G protein is bound to GTP in resting state

Correct Answer: G proteins act as inhibitory and excitatory because of difference in alpha subunit

Description: Heteromeric g protein located inside the cell are activated by g protein coupled receptors that span the cell membrane. Signaling molecules bind to a domain of GPCR out side the cell and an intracellular GPCR domain then in turn activates a paicular G protein Ref:Guyton and Hall textbook of medical physiology 12th edition,page number:540,541,542

Category: Physiology

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