Which of the following is not synthesised from mevalonate?
Correct Answer: Ubiquitin
Description: Cholesterol synthetic pathway is also involved in the synthesis of many other impoant compounds such as: Farnesyl pyrophosphate and geranyl pyrophosphate - involved in prenylation of proteins. Dolichol - involved in N-glycosylation of proteins in endoplasmic reticulum. Ubiquinone (Q10) - is the electron carrier in the mitochondrial respiratory chain. Inhibition of ubiquinone synthesis is one of the reasons for statin-induced myopathy. Ubiquitin protein is not synthesized by any of the cholesterol synthesis pathway intermediate.
Category:
Biochemistry
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