The main site of urea synthesis in mammals is:
Correct Answer: Liver
Description: The intracellular ammonia is immediately trapped by glutamic acid to form glutamine, especially in brain cells. The glutamine is then transported to liver, where the reaction is reversed by the enzyme glutaminase . The ammonia thus generated is immediately detoxified into urea.
Reference: Vasudevan 7th ed, pg 203
Category:
Biochemistry
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