Which is NOT TRUE with regards to antibiotic resistance in bacteria?
Correct Answer: Plasmid mediated resistance is transmitted only veically
Description: Plasmid mediated resistance can be transmitted both horizontally and veically. Routes of horizontal transfer of plasmid mediated resistance are conjugation, transduction and transformation. 3 main mechanisms of drug resistance: Production of beta lactamases: Most common mechanism of penicillin resistance in both gram +ve and -ve bacteria. Alteration of PBP (penicillin binding proteins ): Seen in gram +ve bacteria. This is the basis for methicillin resistance in MRSA also basis for penicillin resistance in pneumococci and enterococci. Impaired penetration: Seen only in gram -ve bacteria PBP are localised on outer surface of cell membrane and not on cell wall. PBP are essential for synthesis of cell wall.
Category:
Microbiology
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