Wof antimetabolite anti neoplastic agent is used in treatment of mesothelioma
Correct Answer: Pemetrexed
Description: Pemetrexed Mech of action:- The newer congener of Mtx primarily targets the enzyme thymidylate synthase. Though, it is also a DHFRase inhibitor, the pool of THFA is not markedly reduced. Adverse effects:- mucositis, diarrhoea, myelosuppression, itching, erythematous rash mostly involving the hands and feet, 'hand- foot syndrome' is quite common. Dexamethasone can relieve it. Uses:- In combination with cisplatin,pemetrexed is approved for treatment of mesoepithelioma and non-small cell lung carcinoma. Ref:- kd tripathi; pg num:-863
Category:
Pharmacology
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