Activation of which of the following hormone’s receptors produces E.Coli induced diarrhoea?
Correct Answer: Guanylin
Description: Guanylin is a gastrointestinal polypeptide that binds to guanylyl cyclase. It is secreted by cells of the intestinal mucosa. Stimulation of guanylyl cyclase increases the concentration of intracellular cyclic 3',5'-guanosine monophosphate (cGMP), and this in turn causes increased secretion of Cl- into the intestinal lumen. The heat-stable enterotoxin of ceain diarrhea-producing strains of Escherichia coli has a structure very similar to guanylin and activates guanylin receptors in the intestine.
Category:
Physiology
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