All of the following diuretics inhibit Na+.K+.2Cl- symporter, EXCEPT:
Correct Answer: Thiazide
Description: 1. High efficacy diuretics (Inhibitors of Na-K-2Cl cotransport)
Sulphamoyl derivatives - Furosemide, Bumetanide, Torsemide.
2.Medium efficacy diuretics (Inhibitors of Na-Cl symport)
(a) Benzothiadiazines (thiazides)- Hydrochlorothiazide, Benzthiazide, Hydroflumethiazide, Clopamide.
(b) Thiazide-like (related heterocyclics) - Chlorthalidone, Metolazone, Xipamide, Indapamide.
3. Weak or adjunctive diuretics
(a) Carbonic anhydrase inhibitors - Acetazolamide.
(b) Potassium-sparing diuretics.
(i) Aldosterone antagonist: Spironolactone
(ii) Inhibitors of the renal epithelial Na+ channel: Triamterene, Amiloride.
(c) Osmotic diuretics - Mannitol, Isosorbide, Glycerol.
Category:
Pharmacology
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