Which of the following is not seen on hemoglobin electrophoresis in sickle cell anemia
Correct Answer: HbA
Description: Ref Harrison 19 th ed pg 634 sickle cell syndromes are caused by a mutation in the b-globin gene that changes the sixth amino acid from glutamic acid to valine. HbS (a2 b2 6 Glu-Val) polymerizes reversibly when deoxygenated . No beta chains and therfther no HbA
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